Antibodies to parietal cells gastritis

Blood tests for antibodies to parietal cells, Parietal cells al. (stomach) serum

This test is used to aid in the diagnosis of autoimmune mastritis and pernicious anemia.
To find out the cause of a lowered vitamin B12 level.

Autoimmune gastritis is a condition in which the immune system attacks its own cells in the stomach. As a result, the mucous membrane on the inside of the stomach becomes permanently damaged. This can cause a pernicious anemia. Pernicious anemia is therefore not an isolated condition. It occurs only as a result of an autoimmune gastritis.

Pernicious anemia is a certain type of anemia that can occur as a result of autoimmune gastritis. This is a condition in which the mucous membrane in the stomach may be permanently damaged and certain vitamins cannot be absorbed.

In pernicious anemia, there is a vitamin B12 deficiency. This can eventually cause (permanent) symptoms. Autoimmune gastritis is also called type-A gastritis or chronic gastritis.

In addition to this test, the test for antibodies to intrinsic factor is also recommended to determine the cause of pernicious anemia.

Chronic or atrophic gastritis often produces few or only vague symptoms. Symptoms that may occur are:

• pain in the stomach area
• nausea
• bloating
• lack of appetite
• heartburn
• sometimes vomit

Long-term consequences

In chronic gastritis, the gastric mucosa can change permanently. One consequence is that the mucous membrane becomes thinner and thinner. This is called atrophic gastritis (atrophy is the shrinking or shriveling of tissue). Atrophic gastritis is usually the result of chronic type A gastritis (autoimmune gastritis).

A vitamin B12 deficiency caused by atrophic gastritis is also called pernicious anemia. In the long run, other symptoms may also occur. Recognizable by pernicious anemia are especially a painful tongue, fatigue, lightheadedness and pale vision. Because the body has large reserves of vitamin B12, it can take several years before a vitamin B12 deficiency develops. For early detection, the Holo TC test is the most suitable.

explanation of results AUTOANTILICHAMEN v Parietal cells
Unit of measurement is: U/ml

• If the result is less than 7, no parietal cells are found. Negative < 7.
• If the result is between 7 and 10, the result is questionable.
• If the result is positive, the result is not good. This is when the blood value is above 10.

Autoantibodies to Parietal cells occur in:

• pernicious anemia (90%)
• idiopathic chronic pancreatitis, inflammation of the pancreas (50%)
• hereditary blood (poverty) diseases (about 40%)
• atrophic gastritis type A (about 35%)
• Thyroid disorders (about 33%)