Beta-trace protein in Sekret

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Beta-trace protein, also known as Prostaglandin D Synthase (PGDS), is another biologically significant protein often used in medical diagnostics. Like beta-2-transferrin, beta-trace protein plays a role in detecting cerebrospinal fluid (CSF) leakage, but it also has other functions and is found in various body fluids.

Functions and Occurrence

Beta-trace protein is involved in the synthesis of prostaglandin D2, an important mediator of inflammatory and allergic reactions. The protein is found in numerous tissues and fluids, including cerebrospinal fluid, serum, urine, and tears. It is one of the most abundant proteins in cerebrospinal fluid.

Use in Diagnostics

The concentration of beta-trace protein in cerebrospinal fluid is much higher than in blood serum, making it a useful biomarker for detecting CSF leakage. In cases of suspected CSF leakage, such as after head trauma, surgery or in symptoms such as rhinorrhea (leakage of fluid from the nose) or otorrhea (leakage of fluid from the ear), measuring beta-trace protein in the suspected fluid can help confirm whether it is indeed CSF.

Comparison with Beta-2-Transferrin

Although beta-2-transferrin is highly specific for CSF and perilymph, beta-trace protein provides an alternative marker that may also be useful, especially in situations where beta-2-transferrin testing is not available or when additional confirmation is needed. Tests for beta-trace protein are generally less expensive and may be more readily available in some laboratories.

In some medical scenarios, testing for both beta-trace protein and beta-2-transferrin are performed to increase the accuracy of diagnosis of CSF leakage. Understanding and applying these proteins in clinical settings significantly improves the treatment and management of patients with potential leaks of cerebrospinal fluid.