Mitochondrial dysfunction urine HCL test RP

Research on mitochondrial dysfunction and metabolic processes

Energy metabolism

This research is aimed at identifying mitochondrial dysfunction, which could potentially be the cause of a variety of symptoms such as fatigue, muscle weakness, or neurological problems. The mitochondria, the power plants of our cells, play a crucial role in energy production through the citric acid cycle (also called the Krebs cycle). When these processes are disrupted, it can lead to a range of health problems.

The study measures specific organic acids that directly reflect the functioning of the citric acid cycle. Urinalysis identifies the levels of these organic acids, which provides insight into how well the mitochondria are functioning and how metabolic processes are occurring.

nergy production, nutrient cofactor requirements and neurotransmitter metabolism.

This study examines the following organic acids and metabolites from acidified urine: malic acid, succinic acid, aconitic acid, fumaric acid, lactate, pyruvate, citric acid, lactate/pyruvate index and alpha-ketoglutaric acid.

This test can reveal whether mitochondrial dysfunction may be the cause of symptoms. The Energy metabolism test consists of an Urine HCL test and provides a broad picture of cellular and physiological processes.

What is measured?

1. 1. Pyruvate:

      • Elevated pyruvate may indicate impaired mitochondrial function and reduced oxygenation of cells. This may result in inefficient energy production.

   2. Lactate:

      • Elevated lactate often indicates anaerobic energy production. This means the body produces energy without the use of oxygen, which is less efficient and can lead to muscle fatigue and soreness.

   3. Lactate/pyruvate index:

      • This ratio provides insight into the balance between aerobic and anaerobic energy production. An abnormal index may indicate disturbances in mitochondrial function and be a possible cause of fatigue symptoms.

   4. Citric acid:

      • Citric acid plays a key role in the citric acid cycle. Increased or decreased levels may indicate a disturbance in energy production from fats and carbohydrates.

   5. Alpha-ketoglutaric acid:

      • This acid is an essential intermediate in the citric acid cycle. An abnormality in the level of alpha-ketoglutaric acid may indicate inefficiencies in mitochondrial energy production and impaired metabolism.

   6. Pelic acid (Malonic acid):

      • Increased pelic acid may indicate inefficient burning of fatty acids, which may be a sign of mitochondrial dysfunction.

   7. Succinic Acid (Succinate):

      • Succinic acid is an important intermediate in the citric acid cycle. Disturbed levels may indicate problems in the mitochondria and may be an indication of impaired energy production.

   8. Aconitic acid:

      • Aconitic acid is involved in the conversion of citric acid to isocitric acid within the citric acid cycle. Abnormalities in this acid may be an indication of decreased efficiency in energy production.

   9. Fumaric acid:

      • Fumaric acid is another intermediate in the citric acid cycle, and abnormal levels may indicate problems in mitochondrial function and general metabolism.

What does this mean to you?

The measurement of these organic acids provides important information about the functioning of your mitochondria. For example, a disruption in the citric acid cycle can contribute to decreased energy production and a wide range of symptoms, from chronic fatigue to neurological disorders. By examining which processes are disrupted, targeted treatment can be initiated to improve mitochondrial function and alleviate symptoms.

With the results of this study, possible mitochondrial dysfunctions can be identified, which will help you and your doctor understand the underlying cause of your symptoms and take appropriate follow-up treatment steps.