M2-Pyruvate kinase in stool
M2PK from feces for screening or monitoring of colon cancer. (tube with brown cap)
This test can only be ordered by therapists, not by consumers.
7-22: This test is no longer done by Blood Values Test, it is too specialized and is only done in 3rd line hospitals.
This test is only for people up to age 55, after that you are covered by the population screening, where you will be tested for colon cancer every two years for free until age 75.
The gold standard for follow-up testing after a positive result from the population screening is a colonoscopy.
Increased values of M2-PK in the stool are found in colon cancer, but also in inflammatory bowel diseases and infectious diarrhea.
Alternatively, if colorectal cancer is suspected, stool hemoglobin and stool hemoglobin-haptoglobin complex are recommended.
A negative test result provides only 83% certainty that there is no colon cancer.
https://pubmed.ncbi.nlm.nih.gov/29626277/
M2PK in stool can be used as a screening test for colonoscopy when colorectal cancer is suspected. This test is superior to other tumor markers and in indicating the progression of colorectal adenomas > 1 cm. Because it is a cost-effective and easy-to-perform test, it is a feasible tool for selecting patients who require colonoscopy.
Although invasive colonoscopy is the gold standard for patients at risk for colorectal cancer, it is a good non-invasive and specific marker as a pre-selection or monitoring tool.
Follow-up testing after a positive result from the population screening is a colonoscopy.
