MTHFR gene mutation C677T

Genetic testing for MTHFR gene mutation C677T + Declaration of Consent

Gene-defect conversion of FolateResearch
has shown that the conversion of Folate and food-Folates to active Folate is not optimal in about half of the European population.
This is due to a gene defect called C677T in the MTHFR gene. The MTHFR gene is required to convert folic acid to active folate. With gene defect C677T, the activity of the MTHFR gene is reduced by 30 to 45%. This means that it takes longer for the body to convert folic acid and food folates into active folate. In the Netherlands about 40% of the population suffers from gene defect C677T. This does not have to have negative effects but can be a reason for existing complaints.
A common side effect of this gene defect is a high homocysteine value.

A defect of the MTHFR gene gives reduced function of this MTHFR enzyme.
As a result, no or reduced bioactive folate can be formed.
This can have major health implications. 5-MTHF, the bioactive form of folic acid is needed for the body to make its own bioactive vitamin B12, methylcobalamin.

This gene mutation affects:

• Methylation The process in the body that creates antioxidants, processes toxins, and creates dopamine, serotonin, melatonin, noradrenaline, and adrenaline.
• Quality of the immune system
• The ability to detoxify the body
• DNA construction and repair/regeneration capacity
• The ability to produce neurotransmitters
• The ability to make energy, ATP (muscle fuel)
• The ability to make biologically active vitamin B12, methylcobalamin, itself

For this study, you must sign a consent form and send it along to the laboratory. You will find this in the package you will be sent.

Please note, this test is also included in the iGene research for a lower price!
Developments in DNA research are going fast, new techniques make it possible to analyze multiple genes for a lower price.



This test can be part of the iGene test, if you explicitly request it during the ordering process at "Remarks".