Muconic acid for monitoring Benzol

Muconic acid is considered an important bio-based platform chemical for the production of valuable consumer products such as bioplastics, including nylon-6,6 and polyurethane. It is a metabolite of benzol in humans and is therefore used as a biomarker for benzol exposure, which is especially important in occupational and environmental monitoring. The acid can also be prepared synthetically from adipic acid and occurs in some bacteria as part of the degradation of aromatic compounds

- Health and Safety Service Use

Synonym: 2,4-Hexadiendisäure

Categories: Occupational & Environmental Medicine, Organic Tax Substances, Toxicology

Sample Requirements: 1 ml of spontaneous urine

Preanalytical: Immediately after exposure or after the working day

Standard values: EKA value 2.0 mg/l or 1.5 mg/g Creatinine at a benzolex exposure of 3.3 mg/m³

Method: HPLC (High-Performance Liquid Chromatography)

Clinical Indication: Medical surveillance of benzol exposure in the workplace. t,t-Muconsäure, a metabolite of benzol, is used to assess long-term exposure to benzol.

Assessment: Benzol, a volatile aromatic hydrocarbon belonging to the "BTXE" group (Benzol-Toluol-Xylol-Ethylbenzol), is a proven carcinogen. About 90% to 95% of benzole emissions come from road traffic.

Implementation Test: By the user himself

Accreditation: Yes, according to ISO 15189

This test is essential for employers and occupational health departments to monitor benzol exposure in workers, especially in industries where benzol is frequently used, to reduce health risks from chronic exposure.

Reporting to company physician or employees. For more than 10 individuals, the company may have a group report prepared for reporting to employer, not traceable to the individual.