Pyridinoline, deoxypyridinoline in urine

Crosslinks in urine. (10 ml Pyidionolin (PYD) (PYRIU PYRICR tube shield with aluminum foil against light)

Synonyms pyridinoline, deoxypyridinoline in urine, Pyridinoline in urine

This test here says bone metabolism.

Collect urine up to about 9:00 a.m. Second morning urine, aluminum foil around the tube against light.

The N-telopeptide and creatinine are used to calculate the ratio of N-telo to Creatinine: This ratio referred to as "NTx".

This test can be done at:
1. Menopausal women not receiving hormone replacement therapy(HST): Women with a baseline NTx value higher than 38 have a significant risk of a decrease in bone mineral
density (BMD= Bone Mineral Density) after 1 year, compared with women using HST (hormone replacement therapy).
The probability of a decrease in BMD increases with NTx value. Baseline NTx Probability of decrease in BMD
18-38 1.4 p = 0.28
38-51 2,5 p = 0,03
51-67 3,8 p = 0,0006
67-188 17,3 p = 0,0001

2. Menopausal women receiving antiresorptive therapy (drug treatment against osteoporosis): The probability that treatment is effective after three months is increased when the measured NTx value has decreased more than 30% from the first measurement.

3. Patients with Paget's bone disease:
Treatment is more likely to be effective after one month when the measured NTx value is within is the reference range, or NTx has decreased by more than 30%

reference values♀
94.6 - 315 µg / g Crea♂
87.5 - 247 µg / g Crea

Measurement Method Used: High-Performance-Liquid-Chromatography (HPLC)

For Diagnosis and follow-up, therapy monitoring in increased bone resorption (osteoporosis) and increased cartilage degradation.
An elevated result indicates: bone and cartilage degradation in osteoporosis, hyperparathyroidism, hyperthyroidism, Paget's disease, bone metastases, therapy with corticoids, physiological bone growth. Deoxypyridinoline is bone specific.

Paget's disease

Paget's disease is an inflammatory-like condition of your bone that leads to deformation of your bone. The balance between bone production and bone breakdown is disturbed. Your bone is broken down faster than normal because of this. New bone is made, but it is sloppy and not as orderly as normal bone production. The new bone is softer and more brittle so it bends or breaks faster. Also, the new bone is larger than the original bone. You may have pain from the affected bone.

Paget's disease is a long-standing (chronic) bone disorder. The condition is named after Sir James Paget, who was the first to describe it.

Common spotsFor
most people, the condition occurs in the pelvis. Other common sites include:

• the bones of your back (the spine and sacrum)
• the bones of your head (the skull)
• The bones of your arms and legs.

In more than half of people with Paget's bone disease, more bones are affected at once, but the condition does not spread to other bones.

Especially over 55 years of
agePaget's bone disease occurs in about 3.5% of people over 55 years of age. It almost never occurs in people younger than 40. Slightly more men than women get the condition. Proper treatment is important to prevent the bone from becoming increasingly affected and to prevent additional problems.