Estrogen metabolites RP

Estrogen metabolites are measured in Urine (RP test kit urine).
2-OHE1, 2-MeOE1, 4-MeOE1, 16a-OHE1, 4-OHE1,

ratio
:2-OHE1/16a-OHE1

Estrogens are processed in the liver into so-called metabolites (metabolic products). These are water-soluble forms of estrogen so that the hormone can be excreted through urine and feces. Estrogen itself is a fatty substance and therefore cannot be excreted directly.

There are five metabolites of estrogen. However, these five metabolites still have estrogenic effects. Some metabolites work more powerfully and specifically than others.

Mild, protective action:

-2OH estrone

Strong, tumor-stimulating effect:

-4OH estrone

-16aOH estrone

These hormones control cell division in estrogen-sensitive cells.

Inactive metabolites:

-2 methoxy-oestrone

-4 methoxy-oestrone

These metabolites can, however, occupy an estrogen receptor and thus prevent the active metabolites from causing cell division.

Through the determination of the metabolites 2-OH and 16aOH and their relationship to each other, a picture of changes in estrogen metabolism can be formed.

The interrelationship of these metabolites often determines the degree to which women experience symptoms that can be classified as estrogen dominance such as:

• Premenstrual syndrome (PMS)
• Heavy menstruation
• Painful menstruations
• Menstrual migraines and hormonal headaches Sore breasts
• Lump formation in breasts
• Cyst formation of the ovaries Abnormal smears
• Endometriosis

Estrogen dominance symptoms need not be caused (exclusively) by unfavorable estrogen metabolism. The symptoms can also be caused or aggravated by progesterone deficiency, by high stress hormone production and by insulin resistance.

Several studies suggest that estrogens are associated with an increased risk of carcinoma. Postmenopausal women with the highest 2-OH/16aOH ratio (2-OH> : < 16aOH), have a 30% lower risk of breast cancer. Premenopausal women with breast cancer had a higher proportion of 16aOH relative to 2-OH than healthy women.

The individual 2-OH/16aOH ratio is not entirely genetic. A large proportion is determined by diet a lifestyle. In particular, indol-3-carbinol, a component of cruciferous vegetables such as broccoli, cabbage, or cauliflower, has a beneficial effect. One to two meals a day with these vegetables can significantly reduce the risk of breast cancer. Soy protein also improves the 2-OH/16aOH ratio. The same is true of the omega-3 fatty acids EPA and DHA from fish.

2-MEOE1

An inactive estrogen metabolite. This metabolite can occupy an estrogen receptor, however, and thus prevents the active metabolites from causing cell division.

2-OHE1

This estrogen metabolite has mild estrogenic and protective effects.

4-MEOE1

An inactive estrogen metabolite. This metabolite can occupy an estrogen receptor, however, and thus prevents the active metabolites from causing cell division.

4OHE1 AND 16A-OHE1

An estrogen metabolite with strong estrogenic, tumor-stimulating effects. This hormone controls cell division in estrogen-sensitive cells.