Orthobalance Combi Lyme Test CD 57+ and WesternBlot

This Lyme combination test of CD57 (EDTA) and IgG Blot Lyme Borrelia (serum) has been formulated to assess the situation of Chronic Lyme.

Lyme disease is an infectious disease caused by the bacteria Borrelia.

CD57 test

This test measures via antigens the number of CD57 lymphocytes, a certain type of blood cells that help clear infections. Chronic Lyme patients in particular are thought to have a low number of CD57 cells. With antibiotic treatment and recovery from the disease, this number would go back up, according to some ILADS doctors (An LLMD Lyme literate medical doctor, means a doctor who has done a scientific publication on Lyme).

Also in several other diseases the CD57 cell count can be lowered and there are also some chronic Lyme patients who do have a normal or high CD57 score.

The CD57+ cells give an indication about the degree of immunosuppression of chronic Lyme disease. Based on current literature, CD57+ cells are predictive laboratory parameters during and after treatment of chronic Lyme disease.

Clinical studies and case reports have shown that chronic Lyme infections are often associated with changes in the cellular immune system. Evidence for this is a decreased number of Natural Killer cells (NK/CD3-CD56+) that you can do through this test, but in particular a decreased absolute number of activated NK cells (CD3-CD56+ CD57+). While acute Borrelia burgdorferi infections and other diseases have normal CD57 values, chronic Lyme patients often have less than 100 CD57 cells/µl.

According to scientific studies, a suppressed CD57 cell count is mainly observed in patients in whom the nervous system is affected, rather than in patients in whom the tissue or skeletal system is affected. The decrease in CD57 cells persists until improvements in symptoms are achieved as a result of antibiotics and other forms of treatment. Conversely, decreased CD57 is considered a parameter for active chronic Borrelia infection and a possible indication that therapy has not yet taken hold.

The result is good if CD57+/CD8+ is between 60-360 cells per ul.

The IgG Westernblot test shows Borrelia antibodies.
This test is also called the Borrelia confirmation test for Lyme disease.

A Borrelia infection proceeds in different stages :
Stage I (days to weeks):
Erythema migrans occurs on average 2 to 3 weeks after the tick bite. There is a red spot that slowly becomes larger. This looks like a red ring with a paler color in the middle. Sometimes people feel flu-like, Sometimes facial paralysis as well.Stage
II (after weeks to months):
redness of the skin, lymphocytoma (The preferred sites for the lymphocytoma are the earlobe in children and the breast and nipple in adults), inflammation of the heart, meningitis, inflammation of a nerve where it exits the spinal cord.Stage
III (after years):
Arthritis (joint inflammation), Acrodermatitis chronica atrophicans (ACA) is a little known, late cutaneous manifestation of lyme borreliosis discolored skin and swollen joints, chronic fatigue syndrome.

Method used Westernblot ImmunoblotThe
result is good if it is negative

The formation of antibodies depends on the stage of the disease
:Stage I: about 50%Stage
II: about 70%Stage
III: about 90%.

However, this varies from person to person. After the infection has healed, IgG antibodies may remain detectable for a long time.

See also https://lci.rivm.nl/richtlijnen/lymeziekte