Polymorphonuclear elastase in stool

Polymorphonuclear elastase (PMN-Elastase) from stool is
an enzyme released during inflammatory reactions in the intestinal tract. Polymorphonuclear (PMN) granulocytes play an important role as primary defense cells in inflammatory responses to attacks by invading microorganisms and viruses or damaged tissue (after accidents or surgery). Normally, PMN Elastase is not detected in the stool or only in small amounts.

Physiologically, this enzyme participates in the intracellular degradation of phagocytosed material. If a degranulation of leukocytes occurs due to an inflammatory response, PMN Elastase is also released. Normally, PMN Elastase is not detected in the stool or only in small amounts.

Reference Value
PMN Elastase
Max.

Unit

Reference Value

135

ng/ml

Therapeutic value

120

ng/ml

Interpretation research result
Increased value

PMN Elastase is used as a biochemical biomarker for the pathological stimulation of granulocytes. An elevated value indicates a (chronic) inflammatory response in the gastrointestinal tract, so in Crohn's disease and ulcerative colitis the value is elevated.

The result is good if it is lower than 135 ng/ml. preferably lower than 120.

Increased value

An elevated value indicates a (chronic) inflammatory response in the gastrointestinal tract, so in Crohn's disease and ulcerative colitis the value is elevated.

Using the Fe-Col®, a stool collector that can be attached around the toilet seat, stool can be collected from the paper with the scoop or comb of the tube.
The tube should be at least half full with preferably feces from about 6 different spots. Write name and date of birth on the tube.