Pregabalin (Mirror determination) for psychiatrists

Pregabalin (Mirror Determination) Please use serum without gel for this study. (serum black cap)

Synonyms: Lyrica Categories: Antiepileptics, Drug levels

Purpose of Test: This test is used for therapy monitoring and observation of pregabalin, a medication used primarily for the treatment of epilepsy, neuropathic pain, and as adjunctive therapy in generalized anxiety disorders. Measuring the concentration of pregabalin in the blood helps determine dosage effectiveness and minimize side effects by maintaining a therapeutic range.

Preanalytics:

• Blood draw immediately before the next medication intake

Reference values:

• Therapeutic range: 2 - 5 µg/ml
• Toxic: > 10 µg/ml

Method:

• LCMS: Liquid chromatography-mass spectrometry

Clinical indication:

• The mirror determination of pregabalin is intended to control and monitor pregabalin treatment to ensure that the medication is effective and remains within a safe range.

Psychiatrists use mirror determination of pregabalin for several reasons, all aimed at optimizing treatment for their patients. Here are the main reasons for using this test:

Determining the effective dose: Pregabalin is used to treat several conditions, including epilepsy, neuropathic pain, and generalized anxiety disorders. The effectiveness of treatment can vary greatly between individuals, depending on their metabolism, age, weight, and use of other medications. By measuring the concentration of pregabalin in the blood, psychiatrists can determine whether the current dose is within the therapeutic range (2 - 5 µg/ml), indicating that it is likely to be effective without causing harmful side effects.

Preventing side effects and toxicity: Overdosing pregabalin can lead to unwanted side effects or even toxicity (> 10 µg/ml). Psychiatrists use this test to adjust the dosage and minimize the risk of side effects, especially in cases where patients are drug sensitive or take multiple medications at the same time.

Therapy adherence monitoring: The mirror determination can also provide insight into the patient's compliance. If the measured concentration of pregabalin is lower than expected, this may indicate that the patient is not taking the drug correctly. This provides a starting point for the psychiatrist to discuss the importance of adherence and overcome any obstacles to this with the patient.

Personalization of treatment: Each individual responds differently to medication, and what works for one patient may be ineffective or harmful for another. Mirroring allows psychiatrists to personalize treatment based on the patient's specific needs and reactions, increasing the likelihood of success.

Adjusting treatment: Over time, a patient's needs may change, or the body may begin to respond differently to pregabalin. Regular mirror determinations help psychiatrists notice these changes and adjust the dosage accordingly.